Epigenetic Inheritance of Disease and Disease Risk
نویسندگان
چکیده
منابع مشابه
Environmentally induced epigenetic transgenerational inheritance of phenotype and disease.
Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the deve...
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The genome of eukaryotic organisms is compacted in the nucleus in a manner that allows transmission of the genetic material between generations and access of the replication and transcription machinery to the DNA. Expression or repression of specific genes is accompanied by alterations in the local chromatin carried out by DNA methyl transferases, histone modifying enzymes, ATP-dependent chroma...
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Epigenetic marks in mammals are essential to properly control the activity of the genome. They are dynamically regulated during development and adulthood, and can be modulated by environmental factors throughout life. Changes in the epigenetic profile of a cell can be positive and favor the expression of advantageous genes such as those linked to cell signaling and tumor suppression. However, t...
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The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestating female rat during embryonic gonadal sex determination, the F1 and F3 generation progeny adult o...
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That there is a heritable or familial component of susceptibility to chronic non-communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non-genomically and that the processes whereby environmental influences act during early development to shape disease risk i...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2012
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2012.110